Simone may refer to:

  • S1m0ne, a 2002 science fiction drama film
  • Simone (actress), the stage name of Lisa Celeste Stroud, daughter of Nina Simone
  • Simone (character), a fictional character in the ABC Family show The Nine Lives of Chloe King
  • Simone (given name), a feminine (or masculine, in Italian) given name of Hebrew origin
  • Simone (surname), a surname
  • Simone (singer), a Danish singer
  • Simone Bittencourt de Oliveira, a Brazilian singer and performer
  • Tropical Storm Simone (disambiguation), two tropical cyclones in the Eastern Pacific Ocean