Domains
Adaptor proteins usually contain several domains within their structure (e.g., Src homology 2 (SH2) and SH3 domains) which allow specific interactions with several other specific proteins. SH2 domains recognise specific amino acid sequences within proteins containing phosphotyrosine residues and SH3 domains recognise proline-rich sequences within specific peptide sequence contexts of proteins.
There are many other types of interaction domains found within adaptor and other signalling proteins which allow a rich diversity of specific and coordinated protein–protein interactions to occur within the cell during signal transduction.
Read more about this topic: Signal Transducing Adaptor Protein
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