SICA can refer to:
- Central American Integration System (Sistema de la Integración Centroamericana/Système d'intégration centraméricaine)
- Subud International Cultural Association
- Solomon Islands Christian Association
- SICA (high school sports) (South Inter-Conference Association), an Illinois high school athletic conference
- a sica, was the standard weapon used by a Thracian gladiator in Ancient Rome.
- South Indian Cultural Association, Hyderabad
- South Indian Cultural Association, Indore
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