Application
Dihydroxylation in the absence of a coordinating ligand requires the use of a stoichiometric amount of osmium. Catalytic, asymmetric dihydroxylation reduces the cost of this procedure 99.9%, opening the door for advances in biomimetic and sympathetic osmates.
Asymmetric dihydroxylation has been applied to alkenes of every substitution, and high enantioselectivities have been realized for every substitution pattern. Asymmetric dihydroxylation reactions are also highly site selective, providing products derived from reaction of the most electron-rich double bond in the substrate.
Read more about this topic: Sharpless Asymmetric Dihydroxylation
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