Self-experimentation - Chemistry

Chemistry

Until recently, it was common practice among synthetic chemists to taste newly prepared compounds. The purpose was to provide an additional characteristic for identification, taking advantage of the selective chemical receptors that form this sense. However, as one might guess, this practice also led to numerous fatalities and near-fatalities. Surprisingly, it was not recognition of the risk of this self-experimentation that led to its extinction, but rather the advent of instrumentation capable of exacting physical characterization of compounds (particularly spectrometers with infrared, ultraviolet, NMR and mass selectivity). The routine tasting of new compounds by chemists of bygone times is, in fact, the main source of knowledge of the human toxicity for certain chemicals.

This practice had positive and negative aspects. It probably contributed to the death of Carl Wilhelm Scheele from apparent mercury poisoning. Joseph Priestley discovered soda water while experimenting with carbon dioxide and tasting the results. Dr. Albert Hofmann discovered the psychedelic properties of LSD by accidentally absorbing it—and later intentionally ingesting it—in a self-experiment.

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