SDHB

SDHB

Identifiers Symbols SDHB; CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP External IDs OMIM: 185470 MGI: 1914930 HomoloGene: 2255 GeneCards: SDHB Gene EC number 1.3.5.1

Gene Ontology
Molecular function	• protein binding • succinate dehydrogenase (ubiquinone) activity • electron carrier activity • metal ion binding • ubiquinone binding • 2 iron, 2 sulfur cluster binding • 3 iron, 4 sulfur cluster binding • 4 iron, 4 sulfur cluster binding
Cellular component	• mitochondrion • mitochondrial inner membrane • mitochondrial respiratory chain complex II
Biological process	• tricarboxylic acid cycle • succinate metabolic process • aerobic respiration • respiratory electron transport chain • small molecule metabolic process
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 6390 67680 Ensembl ENSG00000117118 ENSMUSG00000009863 UniProt P21912 Q9CQA3 RefSeq (mRNA) NM_003000 NM_023374 RefSeq (protein) NP_002991 NP_075863 Location (UCSC) Chr 1:
17.35 – 17.38 Mb Chr 4:
140.96 – 140.98 Mb PubMed search

Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene.

The succinate dehydrogenase (also called SDH or Complex II) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. It is also connected to the SDHC/SDHD subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. The subunit is an iron-sulfur protein with three iron-sulfur clusters. It weighs 30 kDa.