Sastre (which means tailor in Spanish) is a surname. Notable people with the surname include:

  • Alfonso Sastre, (born 1926), Spanish playwright
  • Antonio Sastre, (born 1911), Argentinian footballer
  • Carlos Sastre, (born 1975), Spanish cyclist
  • Inés Sastre, (born 1973), Spanish model and actress
  • Lluís Sastre, (born 1986), Spanish footballer
  • Martin Sastre, (born 1976), Uruguayan media artist

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