Sarsaparilla may refer to:
- Several breeds of plants:
- Smilax regelii, also known as Honduran or Jamaican sarsaparilla
- Smilax aristolochiifolia, known as Mexican sarsaparilla
- Smilax aspera, a flowering vine found worldwide
- Alphitonia, known as sarsaparilla in Australia
- Hardenbergia violacea, known as sarsaparilla in Australia
- Aralia nudicaulis, known as wild sarsaparilla
- Hemidesmus indicus, or Indian sarsaparilla
- Sarsaparilla (soft drink), made or flavored with the root of these plants
- The Australian author Patrick White uses Sarsaparilla as name of the fictional town where many of his works take place.