Sandra may refer to:
- Sandra (given name)
- Sandra (singer), popular 1980s German pop singer
- Margaretha Sandra (1629-1674), Dutch woman soldier
- Șandra, a commune in Timiş County, Romania
- Şandra, a village in Beltiug Commune, Satu Mare County, Romania
- Sandra, Estonia, a village
- 1760 Sandra, an asteroid
- Sandra (film), a 1965 Italian film
- SiSoftware Sandra or SiSoftware SANDRA, System ANalyser, Diagnostic and Reporting Assistant, a computer diagnostic and benchmarking software
- Hurricane Sandra, during the 1985 Pacific hurricane season
- "Sandra", a song recorded by Barry Manilow and Dusty Springfield.
- SANDRA (research project), part of the European Union's Framework Programmes for Research and Technological Development
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