Safi may refer to:
- Safi Airways, an Afghan Airline based in Dubai
- Safi, Morocco
- Safi of Persia, a Safavid Shah of Iran
- Safi, Malta, a local council on Malta
- Safi (medicine), an Unani herbal medicine
- Safi (Pashtun tribe)
- Omid Safi, an Iranian-American writer
- Safi (rabbitfish), a type of fish found in the Persian Gulf
- SS Safi, a German cargo ship in service 1956-60