RSE may refer to:
- Companies
- Red Storm Entertainment, a video game company specializing in Tom Clancy licenses
- Rhein-Sieg-Eisenbahn, German railway company
- Organisations
- Royal Society of Edinburgh, Scotland's national academy of science and letters
- Rensselaer Society of Engineers, a local fraternity at Rensselaer Polytechnic Institute (RPI)
- Ramtha's School of Enlightenment, a cult in the United States run by J. Z. Knight
- Other
- Received Pronunciation, also known as Received Standard English
- referenced Single-ended signalling
- Relative standard error, a measure of a statistical estimate's reliability
- Rwanda Stock Exchange, a stock exchange in Rwanda
- Refractory status epilepticus, the persistent form of status epilepticus despite intervention