Romaine may refer to:
- Romaine lettuce, variety of lettuce
- Romaine Vole, a fictional character in Agatha Christie's short story and play "Witness for the Prosecution"
- Ruby Romaine, a fictional character portrayed by Tracey Ullman in the television series "Tracey Takes On..."
Persons with the surname Romaine:
- Irving Romaine (born 1972), Bermudian cricketer
- William Romaine (1714-1795), evangelical divine
- W. H. Romaine-Walker (1854–1940), English architect
Persons with the given name Romaine:
- Romaine Brooks (1874-1970), American painter
- Romaine Fielding (1868-1927), American actor, screenwriter and film director
- Romaine Patterson (born 1978), American gay rights activist, radio personality, and author
Places
- Romaine (Franche-Comté), the Romaine river, in eastern France