Roanoke ( /ˈroʊ.ənoʊk/) may refer to:
- Roanoke tribe, Carolina Algonquian-speaking tribe in eastern North Carolina
- Roanoke (ship), an American ship (1892-1905)
- Roanoke Colony, a former English colony that mysteriously disappeared
- Roanoke Island, location of the Roanoke colony in present-day North Carolina
- Roanoke River, flowing through Virginia and North Carolina and emptying into Albemarle Sound near Roanoke Island
- Roanoke Valley, a part of the Great Appalachian Valley near the headwaters of the Roanoke River in Virginia
- Roanoke, Virginia
- Roanoke County, Virginia
- Roanoke, North Carolina (see Roanoke Colony)
- Roanoke, Illinois
- Roanoke, Indiana
- Roanoke, Texas
- Roanoke, West Virginia
- Roanoke Rapids, North Carolina
- Randolph, Virginia, formerly called Roanoke
Read more about Roanoke: Other References