RET Proto-oncogene

RET Proto-oncogene

Identifiers Symbols RET; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51 External IDs OMIM: 164761 MGI: 97902 HomoloGene: 7517 ChEMBL: 2041 GeneCards: RET Gene EC number 2.7.10.1

Gene Ontology
Molecular function	• protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • receptor activity • calcium ion binding • protein binding • ATP binding
Cellular component	• integral to plasma membrane • endosome membrane
Biological process	• MAPK cascade • ureteric bud development • neural crest cell migration • embryonic epithelial tube formation • protein phosphorylation • homophilic cell adhesion • neuron cell-cell adhesion • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • posterior midgut development • positive regulation of neuron projection development • regulation of cell adhesion • positive regulation of cell migration • membrane protein proteolysis • positive regulation of cell adhesion mediated by integrin • ureter maturation • neuron maturation • positive regulation of transcription, DNA-dependent • response to pain • enteric nervous system development • Peyer's patch morphogenesis • cellular response to retinoic acid • positive regulation of metanephric glomerulus development • lymphocyte migration into lymphoid organs • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5979 19713 Ensembl ENSG00000165731 ENSMUSG00000030110 UniProt P07949 P35546 RefSeq (mRNA) NM_000323 NM_001080780 RefSeq (protein) NP_065681 NP_001074249 Location (UCSC) Chr 10:
43.57 – 43.63 Mb Chr 6:
118.15 – 118.2 Mb PubMed search

The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family of extracellular signalling molecules. RET loss of function mutations are associated with the development of Hirschsprung's disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, pheochromocytoma and parathyroid hyperplasia.