Cast
- Milla Jovovich as Alice and the clones: A woman being tracked down by the Umbrella Corporation in order to develop a serum from her blood. Since being exposed to the T-Virus outbreak in Raccoon City, Alice has been captured and subjected to experiments.
- Ali Larter as Claire Redfield: Based on the video game character of the same name, she plays a prominent role in Resident Evil 2, Resident Evil Code: Veronica and Resident Evil: The Darkside Chronicles. In the film, leads a convoy of survivors alongside Carlos.
- Oded Fehr as Carlos Olivera: Ex-U.B.C.S. soldier, based on the video game character of the same name in Resident Evil 3: Nemesis.He is a survivor of the Nemesis program as well as the "cleansing" of Raccoon City. Since the events of Apocalypse, he has helped lead Claire's convoy of survivors.
- Iain Glen as Dr. Sam Isaacs: The head scientist of the North American facility. Dr. Isaacs had been involved in the creation of the Nemesis program as well as the creation of Program Alice in Apocalypse. He is turned into the Tyrant monster as a result of a bite by a "super-zombie" and from then injecting himself with too much anti-virus. He is based on William Birkin from the video games.
- Ashanti Douglas as Betty: A tough young woman who acts as the medical unit in Claire's convoy. She is a nurse, helping to aid members of the group to full recovery. Betty drives the paramedic vehicle and is a love interest of L.J. She sacrifices herself by locking herself inside the bus with the crows when they attack.
- Christopher Egan as Mikey: A young mature computer junkie who drives the "computer station" portion of the convoy. Mikey is responsible for monitoring the radio in search of other survivors as well as monitoring the motion sensor perimeter cameras. He is killed by the super zombies.
- Spencer Locke as K-Mart: A girl found by Claire's companions hiding out in a K-Mart store prior to the outbreak.
- Matthew Marsden as Captain Slater
- Linden Ashby as Chase
- Jason O'Mara as Albert Wesker: Based on the video game character of the same name, he is a prominent antagonist in many of the video games. In the film, he is the Chairman of Umbrella, and through holographic technology (him being in Tokyo), he has regular meetings with committee members including Dr. Isaacs who gave the order to find and capture Alice.
- Mike Epps as L.J. Wayne: Former citizen of Raccoon City, who survived the Nemesis program and Raccoon City's destruction in the previous film. He also travels with Claire's convoy. He is Betty's love interest. He is bitten by a zombie in the motel near the beginning of the film and later turns into a zombie himself when super-zombies attack.
- Madeline Carroll as The White Queen: The sister computer of the original Red Queen. She is designed to protect and preserve human life and monitor the Umbrella facility, like her sister computer. However, the White Queen has more advanced holographic technology.
Read more about this topic: Resident Evil: Extinction
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