Ranpirnase

Ranpirnase is a ribonuclease enzyme found in Northern Leopard Frog (Rana pipiens) oocytes. It is being studied in the treatment of cancer, specifically in pleural and peritoneal mesothelioma. It is manufactured by Tamir Biotechnology, Inc. (formerly Alfacell Corporation) of Monmouth Junction, NJ and known by the ONCONASE trademark. Onconase has been demonstrated as selectively cytotoxic against tumor cells and has been used empirically to treat malignant mesothelioma patients, with some patients experiencing prolonged survivals.