RANKL

RANKL

Identifiers Symbols TNFSF11; CD254; ODF; OPGL; OPTB2; RANKL; TRANCE; hRANKL2; sOdf External IDs OMIM: 602642 MGI: 1100089 HomoloGene: 2744 GeneCards: TNFSF11 Gene

Gene Ontology
Molecular function	• cytokine activity • tumor necrosis factor receptor binding • tumor necrosis factor receptor superfamily binding
Cellular component	• extracellular region • extracellular space • cytoplasm • integral to plasma membrane
Biological process	• ossification • monocyte chemotaxis • immune response • activation of JUN kinase activity • organ morphogenesis • positive regulation of intracellular protein kinase cascade • cytokine-mediated signaling pathway • osteoclast differentiation • tumor necrosis factor-mediated signaling pathway • mammary gland epithelial cell proliferation • positive regulation of homotypic cell-cell adhesion • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of MAP kinase activity • bone resorption • positive regulation of osteoclast differentiation • positive regulation of bone resorption • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • positive regulation of T cell activation • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • protein homooligomerization • positive regulation of corticotropin-releasing hormone secretion • positive regulation of protein kinase B signaling cascade • mammary gland alveolus development • ERK1 and ERK2 cascade • positive regulation of fever generation by positive regulation of prostaglandin secretion • TNFSF11-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8600 21943 Ensembl ENSG00000120659 ENSMUSG00000022015 UniProt O14788 O35235 RefSeq (mRNA) NM_003701 NM_011613 RefSeq (protein) NP_003692 NP_035743 Location (UCSC) Chr 13:
43.14 – 43.18 Mb Chr 14:
78.28 – 78.31 Mb PubMed search

Not to be confused with RANK, the osteoclast cell-surface receptor that binds to RANKL.

"TRANCE" redirects here. For other uses, see Trance (disambiguation).

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene.

Critical for adequate bone metabolism, this surface-bound molecule (also known as CD254) found on osteoblasts serves to activate osteoclasts, which are the cells involved in bone resorption. Osteoclastic activity is triggered via the osteoblasts' surface-bound RANKL activating the osteoclasts' surface-bound receptor activator of nuclear factor kappa-B (RANK).