In total synthesis, the Quinine total synthesis describes the efforts in synthesis of quinine over a 150 year period. The development of synthetic quinine is considered a milestone in organic chemistry although it has never been produced industrially as a substitute for natural occurring quinine. The subject has also been attended with some controversy: in 2001 Gilbert Stork published the first stereoselective quinine synthesis and he shed doubt (calling it a myth) on the earlier claim in 1944 by Bob Woodward and William Doering on account that they had obtained not quinine but a precursor molecule. In 2001, an editorial in Chemical & Engineering News supported Storks claim but according to a critical 30 page review in this matter published in 2007 in Angewandte Chemie the Woodward/Doering claim is valid.
Read more about Quinine Total Synthesis: Background, Quinine Total Synthesis Timeline, Stork Quinine Total Synthesis, Woodward / Doering Formal Quinine Total Synthesis
Famous quotes containing the words total and/or synthesis:
“The chief lesson of the Depression should never be forgotten. Even our liberty-loving American people will sacrifice their freedom and their democratic principles if their security and their very lives are threatened by another breakdown of our free enterprise system. We can no more afford another general depression than we can afford another total war, if democracy is to survive.”
—Agnes E. Meyer (1887–1970)
“In order to begin an analysis, there must already be a synthesis present in the mind.”
—Johan Huizinga (1872–1945)