Pyr may refer to:
- Pyruvic acid
- Pyridine
- Pyridoxine, vitamin B6. Abbreviation used in tuberculosis treatment regimens.
- Saint Pyr
- Caldey Island, called "Ynys Pyr" in Welsh
- Pyr (publisher)
- PYR is the IATA code for Andravida airbase
- Pyr (Encantadia), a character in the Encantadia franchise