Protein Kinase C - Isozymes

Isozymes

• conventional - require DAG, Ca2+, and phospholipid for activation
  • PKC-α (PRKCA)
  • PKC-β (PRKCB)
  • PKC-γ (PRKCG)
• novel - require DAG but not Ca2+ for activation
  • PKC-δ (PRKCD)
  • PKC-δ1 (PRKD1)
  • PKC-δ2 (PRKD2)
  • PKC-δ3 (PRKD3)
  • PKC-ε (PRKCE)
  • PKC-η (PRKCH)
  • PKC-θ (PRKCQ)
• atypical - require neither Ca2+ nor DAG for activation
  • PKC-ι (PRKCI)
  • PKC-ζ (PRKCZ)
  • PK-N1 (PKN1)
  • PK-N2 (PKN2)
  • PK-N3 (PKN3)