PKC may refer to:
- Paroxysmal kinesogenic choreoathetosis, neurological disorder
- Protein kinase C, a family of enzymes
- Public-key cryptography
- PKC (conference), an acronym for the International Workshop on Practice and Theory in Public Key Cryptography
- Yelizovo Airport or Petropavlovsk-Kamchatsky Airport, an airport located in Petropavlovsk-Kamchatsky, Kamchatka Krai, Russia, whose IATA code is "PKC"
- See also
- The "C" variant of the PK machine gun, a Soviet weapon