Protease Inhibitor (pharmacology) - Antiprotozoal Activity

Antiprotozoal Activity

Researchers are investigating the use of protease inhibitors developed for HIV treatment as anti-protozoals for use against malaria and gastrointestinal protozoal infections:

  • A combination of ritonavir and lopinavir was found to have some effectiveness against Giardia infection.
  • The drugs saquinavir, ritonavir, and lopinavir have been found to have anti-malarial properties.
  • A cysteine protease inhibitor drug was found to cure Chagas disease in mice.

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