Prnp

PRNP

Identifiers Symbols PRNP; ASCR; AltPrP; CD230; CJD; GSS; KURU; PRIP; PrP; PrP27-30; PrP33-35C; PrPc; p27-30 External IDs OMIM: 176640 MGI: 97769 HomoloGene: 7904 ChEMBL: 4869 GeneCards: PRNP Gene

Gene Ontology
Molecular function	• copper ion binding • protein binding • microtubule binding • tubulin binding • identical protein binding • ATP-dependent protein binding • chaperone binding
Cellular component	• nucleus • nucleolus • cytoplasm • endoplasmic reticulum • Golgi apparatus • plasma membrane • extrinsic to membrane • anchored to membrane • intracellular membrane-bounded organelle • membrane raft
Biological process	• negative regulation of protein phosphorylation • cellular copper ion homeostasis • response to oxidative stress • cell cycle arrest • axon guidance • learning or memory • metabolic process • negative regulation of interferon-gamma production • negative regulation of interleukin-17 production • negative regulation of interleukin-2 production • negative regulation of apoptotic process • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of activated T cell proliferation • response to cadmium ion • response to copper ion • negative regulation of T cell receptor signaling pathway • protein homooligomerization • negative regulation of calcineurin-NFAT signaling cascade
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5621 19122 Ensembl ENSG00000171867 ENSMUSG00000079037 UniProt F7VJQ1 P04925 RefSeq (mRNA) NM_000311 NM_011170 RefSeq (protein) NP_000302 NP_035300 Location (UCSC) Chr 20:
4.67 – 4.68 Mb Chr 2:
131.91 – 131.94 Mb PubMed search

Major prion protein (PrP, for prion protein or protease-resistant protein), also known as CD230 (cluster of differentiation 230), is the only known example of a prion protein. In humans, it is encoded by the PRNP gene (PRioN Protein).