PRK could refer to:
- Phase Reversal Keying, see BPSK
- People's Republic of Korea, a short-lived provisional government that aimed to take over control of Korea shortly after the end of World War II
- ISO 3166-1 alpha-3 code, International Olympic Committee country code, and FIFA country code for North Korea, a country evolved from the PRK
- Photorefractive keratectomy, a laser eye surgery procedure
- Port Kent (Amtrak station), New York, United States; Amtrak station code PRK
- People's Republic of Kampuchea, the state that ruled Cambodia after the Vietnamese invasion that defeated the Khmer Rouge
- People's Republic of Kalifornia, a pejorative term referring to California's political environment