PPP1CB

PPP1CB

Identifiers Symbols PPP1CB; PP-1B; PP1B; PP1beta; PPP1CD External IDs OMIM: 600590 MGI: 104871 HomoloGene: 37659 ChEMBL: 4546 GeneCards: PPP1CB Gene EC number 3.1.3.16, 3.1.3.53

Gene Ontology
Molecular function	• protein binding • myosin phosphatase activity • protein kinase binding • metal ion binding • myosin-light-chain-phosphatase activity
Cellular component	• protein phosphatase type 1 complex • nucleoplasm • nucleolus • glycogen granule • MLL5-L complex • PTW/PP1 phosphatase complex
Biological process	• G2/M transition of mitotic cell cycle • mitotic cell cycle • glycogen metabolic process • regulation of glycogen biosynthetic process • regulation of glycogen catabolic process • protein dephosphorylation • lipid metabolic process • transforming growth factor beta receptor signaling pathway • triglyceride catabolic process • regulation of cell adhesion • negative regulation of transforming growth factor beta receptor signaling pathway • small molecule metabolic process • cell division
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 5500 19046 Ensembl ENSG00000213639 ENSMUSG00000014956 UniProt P62140 P62141 RefSeq (mRNA) NM_002709 NM_172707 RefSeq (protein) NP_002700 NP_766295 Location (UCSC) Chr 2:
28.97 – 29.03 Mb Chr 5:
32.46 – 32.52 Mb PubMed search

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.