Powerhouse or Power House may refer to:
- Power station, a facility for the generation of electric power
- Power House (Alcatraz), a powerhouse on Alcatraz Island
- The Power-House, a 1916 novel by John Buchan
- Powerhouse Arts District, Jersey City
- powerHouse Books, a Brooklyn-based publisher of high-end art and photography books
- Powerhouse (club), a gay club in Newcastle upon Tyne
- Powerhouse (comics), the name of several fictional characters in the Marvel Comics Universe
- Powerhouse Museum, a science and technology museum in Sydney, Australia
- PowerHouse (programming language), a 1980s programming language by Cognos Corporation
- Powerhouse (shop), a former electrical goods chain in the United Kingdom
- Powerhouse (TV series), a 1982 United States television series
- Power House (talkshow), a Filipino talkshow
- Powerhouse (video game), a 1995 computer game by Impressions Games, now part of Vivendi SA
- Brisbane Powerhouse, a performing arts center in Brisbane, Queensland, Australia
- Powerhouse, a large club and function center overlooking Albert Park Lake in Melbourne, Victoria, Australia, after which many local recreational clubs are named
- Powerhouse Theater, a collaboration between New York Stage and Film and Vassar College
- Dick Smith Electronics Powerhouse, a chain of large electronics stores operating in Australia and New Zealand
- PowerHouse, a discontinued candy bar manufactured by Peter Paul Candy Manufacturing Company
- "Powerhouse", a short story by Eudora Welty
- In contract bridge, a "powerhouse" is the term given to an unusually strong hand – usually holding very high trumps
Read more about Powerhouse: In Music