Structure
The structure of the PMCA is similar to that of the SERCA calcium pumps, which are responsible for removing calcium from the cytoplasm into the lumen of the sarcoplasmic reticulum. It is thought that the PMCA pump has 10 segments that cross the plasma membrane, with both C and N termini on the inside of the cell. At the C terminus, there is a long "tail" of between 70 and 200 amino acids in length. This tail is thought to be responsible for regulation of the pump.
Read more about this topic: Plasma Membrane Ca2+ ATPase
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