History
PMCAs were first discovered in the 1960s in the membranes of red blood cells. The presence of an ATPase was discovered in the membranes in 1961, and then in 1966 it was discovered that these ATPases pump Ca2+ out of the cytosol.
PMCA was first purified from red blood cell membranes in 1979
Read more about this topic: Plasma Membrane Ca2+ ATPase
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