PKD may stand for:
- Philip K. Dick, science fiction writer
- Kings Dominion, a theme park in Doswell, Virginia, which was known as "Paramount's Kings Dominion" from 1993 to 2006
- PKD, the stock symbol of Parker Drilling Company
- Polycystic kidney disease
- Pyruvate kinase deficiency
- Tetracapsuloides bryosalmonae, or proliferative kidney disease, a disease of salmonid fishes, caused by the myxosporean parasite Tetracapsuloides bryosalmonae
- Paroxysmal kinesogenic dyskinesia, an alternative name for paroxysmal kinesogenic choreoathetosis, a neurological disorder