Limits and Extensions of PBPK Modeling
PBPK models rely and are bounded by chemical property prediction models (QSAR models or predictive chemistry models) on one hand. They also extend into, but are not destined to supplant, systems biology models of metabolic pathways. They are also parallel to physiome models, but do not aim at modeling physiological functions beyond fluid circulation in detail. In fact the above four types of models can reinforce each other when integrated (Bois, 2009, 2010).
Read more about this topic: Physiologically Based Pharmacokinetic Modelling
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