Philadelphia chromosome or Philadelphia translocation is a specific chromosomal abnormality that is associated with chronic myelogenous leukemia (CML). It is the result of a reciprocal translocation between chromosome 9 and 22, and is specifically designated t(9;22)(q34;q11). The presence of this translocation is a highly sensitive test for CML, since 95% of people with CML have this abnormality (the remainder have either a cryptic translocation that is invisible on G-banded chromosome preparations, or a variant translocation involving another chromosome or chromosomes as well as the long arm of chromosomes 9 and 22). However, the presence of the Philadelphia (Ph) chromosome is not sufficiently specific to diagnose CML, since it is also found in acute lymphoblastic leukemia (ALL, 25–30% in adult and 2–10% in pediatric cases) and occasionally in acute myelogenous leukemia (AML).
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Famous quotes containing the words philadelphia and/or chromosome:
“It used to be said that, socially speaking, Philadelphia asked who a person is, New York how much is he worth, and Boston what does he know. Nationally it has now become generally recognized that Boston Society has long cared even more than Philadelphia about the first point and has refined the asking of who a person is to the point of demanding to know who he was. Philadelphia asks about a man’s parents; Boston wants to know about his grandparents.”
—Cleveland Amory (b. 1917)
“We become male automatically because of the Y chromosome and the little magic peanut, but if we are to become men we need the help of other men—we need our fathers to model for us and then to anoint us, we need our buddies to share the coming-of-age rituals with us and to let us join the team of men, and we need myths of heroes to inspire us and to show us the way.”
—Frank Pittman (20th century)