Abl Gene

Abl Gene

Identifiers Symbols ABL1; ABL; JTK7; bcr/abl; c-ABL; p150; v-abl External IDs OMIM: 189980 MGI: 87859 HomoloGene: 3783 ChEMBL: 1862 GeneCards: ABL1 Gene EC number 2.7.10.2

Gene Ontology
Molecular function	• magnesium ion binding • DNA binding • actin monomer binding • nicotinate-nucleotide adenylyltransferase activity • protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • protein binding • ATP binding • protein C-terminus binding • SH3 domain binding • manganese ion binding • mitogen-activated protein kinase binding • proline-rich region binding
Cellular component	• nucleus • nucleolus • cytoplasm • mitochondrion • cytosol • actin cytoskeleton • nuclear membrane • perinuclear region of cytoplasm
Biological process	• regulation of transcription involved in S phase of mitotic cell cycle • mismatch repair • regulation of transcription, DNA-dependent • cellular protein modification process • endocytosis • autophagy • apoptotic process • DNA damage induced protein phosphorylation • cell adhesion • axon guidance • blood coagulation • intrinsic apoptotic signaling pathway in response to DNA damage response • regulation of autophagy • peptidyl-tyrosine phosphorylation • actin cytoskeleton organization • regulation of endocytosis • regulation of cell adhesion • muscle cell differentiation • signal transduction in response to DNA damage • positive regulation of apoptotic process • positive regulation of muscle cell differentiation • positive regulation of oxidoreductase activity • regulation of cell cycle • negative regulation of protein serine/threonine kinase activity • regulation of cell motility • regulation of actin cytoskeleton reorganization • regulation of response to DNA damage stimulus
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 25 11350 Ensembl ENSG00000097007 ENSMUSG00000026842 UniProt P00519 P00520 RefSeq (mRNA) NM_005157.4 NM_001112703.1 RefSeq (protein) NP_005148.2 NP_001106174.1 Location (UCSC) Chr 9:
133.59 – 133.76 Mb Chr 2:
31.69 – 31.8 Mb PubMed search

V-abl Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene located on chromosome 9.