Structure
Like other nuclear receptors, PPARs are modular in structure and contain the following functional domains:
- (A/B) N-terminal region
- (C) DBD (DNA-binding domain)
- (D) flexible hinge region
- (E) LBD (ligand binding domain)
- (F) C-terminal region
The DBD contains two zinc finger motifs, which bind to specific sequences of DNA known as hormone response elements when the receptor is activated. The LBD has an extensive secondary structure consisting of 13 alpha helices and a beta sheet. Natural and synthetic ligands bind to the LBD, either activating or repressing the receptor.
Read more about this topic: Peroxisome Proliferator-activated Receptor
Famous quotes containing the word structure:
“Science is intimately integrated with the whole social structure and cultural tradition. They mutually support one other—only in certain types of society can science flourish, and conversely without a continuous and healthy development and application of science such a society cannot function properly.”
—Talcott Parsons (1902–1979)
“A structure becomes architectural, and not sculptural, when its elements no longer have their justification in nature.”
—Guillaume Apollinaire (1880–1918)
“It is difficult even to choose the adjective
For this blank cold, this sadness without cause.
The great structure has become a minor house.
No turban walks across the lessened floors.
The greenhouse never so badly needed paint.”
—Wallace Stevens (1879–1955)