Antibiotic Target
The following protein synthesis inhibitors target peptidyl transferase:
- Chloramphenicol binds to A2451 and A2452 residues in the 23S rRNA of the ribosome and inhibits peptide bond formation.
- Pleuromutilins also bind to peptidyl transferase.
- Macrolide antibiotics are thought to inhibit peptidyl transferase, in addition to inhibiting ribosomal translocation.
Read more about this topic: Peptidyl Transferase
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