Tenants
- The Consulate of Mexico in Detroit is located in Suite 830.
- The Caucus Club, a restaurant known for hosting influential business officials, was located in Penobscot. In October 2012 it announced that it was closing.
- The tower apex once had "CNB" signs for a local bank that was formerly headquartered in the Penobscot Building.
- It was home to an 80's influential DJ, The Electrofying Mojo, who made nightly visits over Detroit from his 'Mothership'.
- The Smart Detroit Conference Center occupies space on the 13th floor, and includes Class A conference, meeting, or convention space.
- The Wayne County Friend of the Court occupies floors between the sub-basement and eighth floor, making it the current largest tenant of the building.
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