Palumbo is a surname of Italian origin. It could refer to:
- Angy Palumbo (d. 1960), Italian-British musician and composer
- Chuck Palumbo (born 1971), American professional wrestler
- Daryl Palumbo (born 1979), American rock musician
- Dave Palumbo (born 1968), American bodybuilder
- Enrique Loedel Palumbo (1901–1962), Uruguyan-Argentine physicist
- Francisco Minà Palumbo (1814–1899), Italian naturalist
- Frank Palumbo (1910–1983), American restaurateur and philanthropist from Philadelphia, Pennsylvania, USA
- Giuseppe Palumbo (born 1975), Italian bicycle racer
- Joe Palumbo (born 1929), American college football player
- John Palumbo (born 1956), American businessman and motivational speaker
- Luigi Palumbo, Italian footballer
- Peter Palumbo, Baron Palumbo (born 1935), British property developer
- Ruth Ann Palumbo (born 1949), American politician from Kentucky
- Tom Palumbo (born 1921), Italian-American photographer and film director
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