PAK2
Gene Ontology | |
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Molecular function | • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • protein kinase binding • protein tyrosine kinase activator activity • identical protein binding |
Cellular component | • nucleus • cytosol • plasma membrane • perinuclear region of cytoplasm |
Biological process | • protein phosphorylation • negative regulation of protein kinase activity • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • signal transduction • axon guidance • viral reproduction • phosphorylation • peptidyl-serine phosphorylation • virus-host interaction • T cell costimulation • regulation of growth • regulation of apoptotic process • negative regulation of apoptotic process • protein autophosphorylation • regulation of defense response to virus by virus • positive regulation of peptidyl-tyrosine phosphorylation • T cell receptor signaling pathway • positive regulation of protein tyrosine kinase activity • positive regulation of extrinsic apoptotic signaling pathway • negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis |
Sources: Amigo / QuickGO |
196.47 – 196.56 Mb
32.02 – 32.08 Mb
Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene.
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Read more about PAK2: Interactions
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