PAK2

PAK2

Identifiers Symbols PAK2; PAK65; PAKgamma External IDs OMIM: 605022 MGI: 1339984 HomoloGene: 99711 ChEMBL: 4487 GeneCards: PAK2 Gene EC number 2.7.11.1

Gene Ontology
Molecular function	• protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • protein kinase binding • protein tyrosine kinase activator activity • identical protein binding
Cellular component	• nucleus • cytosol • plasma membrane • perinuclear region of cytoplasm
Biological process	• protein phosphorylation • negative regulation of protein kinase activity • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • signal transduction • axon guidance • viral reproduction • phosphorylation • peptidyl-serine phosphorylation • virus-host interaction • T cell costimulation • regulation of growth • regulation of apoptotic process • negative regulation of apoptotic process • protein autophosphorylation • regulation of defense response to virus by virus • positive regulation of peptidyl-tyrosine phosphorylation • T cell receptor signaling pathway • positive regulation of protein tyrosine kinase activity • positive regulation of extrinsic apoptotic signaling pathway • negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5062 224105 Ensembl ENSG00000180370 ENSMUSG00000022781 UniProt Q13177 Q8CIN4 RefSeq (mRNA) NM_002577 NM_177326 RefSeq (protein) NP_002568 NP_796300 Location (UCSC) Chr 3:
196.47 – 196.56 Mb Chr 16:
32.02 – 32.08 Mb PubMed search

Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene.

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.