Otub1

OTUB1

Identifiers Symbols OTUB1; OTB1; OTU1 External IDs OMIM: 608337 MGI: 2147616 HomoloGene: 9772 GeneCards: OTUB1 Gene EC number 3.4.19.12

Gene Ontology
Molecular function	• ubiquitin-specific protease activity • protein binding • omega peptidase activity • NEDD8-specific protease activity • ubiquitin protein ligase binding • ubiquitin binding
Cellular component	• cytoplasm
Biological process	• DNA repair • proteolysis • response to DNA damage stimulus • protein K48-linked deubiquitination • negative regulation of histone H2A K63-linked ubiquitination • negative regulation of double-strand break repair
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 55611 107260 Ensembl ENSG00000167770 ENSMUSG00000024767 UniProt Q96FW1 Q7TQI3 RefSeq (mRNA) NM_017670 NM_134150 RefSeq (protein) NP_060140 NP_598911 Location (UCSC) Chr 11:
63.75 – 63.77 Mb Chr 19:
7.2 – 7.21 Mb PubMed search

Ubiquitin thioesterase OTUB1 also known as otubain-1 is an enzyme that in humans is encoded by the OTUB1 gene. Alternative splicing results in multiple transcript variants.