Osteopontin

Identifiers Symbols SPP1; BNSP; BSPI; ETA-1; OPN External IDs OMIM: 166490 MGI: 98389 HomoloGene: 20156 ChEMBL: 1741309 GeneCards: SPP1 Gene

Gene Ontology
Molecular function	• cytokine activity • extracellular matrix binding
Cellular component	• extracellular region • extracellular space • membrane-bounded vesicle • cell projection • apical part of cell • perinuclear region of cytoplasm
Biological process	• osteoblast differentiation • inflammatory response • cell adhesion • embryo implantation • positive regulation of cell-substrate adhesion • neutrophil chemotaxis • biomineral tissue development • response to vitamin D • positive regulation of bone resorption • decidualization • response to steroid hormone stimulus • negative regulation of collateral sprouting of intact axon in response to injury
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6696 20750 Ensembl ENSG00000118785 ENSMUSG00000029304 UniProt P10451 P10923 RefSeq (mRNA) NM_000582.2 NM_001204201.1 RefSeq (protein) NP_000573.1 NP_001191130.1 Location (UCSC) Chr 4:
88.9 – 88.9 Mb Chr 5:
104.44 – 104.44 Mb PubMed search

Osteopontin

Identifiers

Symbol

Osteopontin

Pfam

PF00865

InterPro

IPR002038

PROSITE

PDOC00689

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

Not to be confused with Osteocalcin, Osteonectin or Osteoprotegerin (OPG).

Osteopontin (OPN), also known as bone sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a human gene product, which is also conserved in other species. Osteopontin is a SIBLING glycoprotein that was first identified in 1986 in osteoblasts.