Types
There are eight different types of OI, Type I being the most common, though the symptoms vary from person to person.
| Type | Description | Gene | OMIM | Mode of Inheritance |
| I | mild | Null COL1A1 allele | 166240 (IA), 166200 (IB) | autosomal dominant, 60% de novo |
| II | severe and usually lethal in the perinatal period | COL1A1, COL1A2, | 166210 (IIA), 610854 (IIB) | autosomal dominant, ~100% de novo |
| III | considered progressive and deforming | COL1A1, COL1A2 | 259420 | autosomal dominant, ~100% de novo |
| IV | deforming, but with normal scleras | COL1A1, COL1A2 | 166220 | autosomal dominant, 60% de novo |
| V | shares the same clinical features of IV, but has unique histologic findings ("mesh-like") | unknown | 610967 | autosomal dominant |
| VI | shares the same clinical features of IV, but has unique histologic findings ("fish scale") | unknown | 610968 | unknown |
| VII | associated with cartilage associated protein | CRTAP | 610682 | autosomal recessive |
| VIII | severe to lethal, associated with the protein leprecan | LEPRE1 | 610915 | autosomal recessive |
Read more about this topic: Osteogenesis Imperfecta
Famous quotes containing the word types:
“Our children evaluate themselves based on the opinions we have of them. When we use harsh words, biting comments, and a sarcastic tone of voice, we plant the seeds of self-doubt in their developing minds.... Children who receive a steady diet of these types of messages end up feeling powerless, inadequate, and unimportant. They start to believe that they are bad, and that they can never do enough.”
—Stephanie Martson (20th century)
“Our major universities are now stuck with an army of pedestrian, toadying careerists, Fifties types who wave around Sixties banners to conceal their record of ruthless, beaverlike tunneling to the top.”
—Camille Paglia (b. 1947)
“The American man is a very simple and cheap mechanism. The American woman I find a complicated and expensive one. Contrasts of feminine types are possible. I am not absolutely sure that there is more than one American man.”
—Henry Brooks Adams (1838–1918)