Morphology and Histological Staining
Hematoxylin and eosin staining, or H&E staining, reveals that the cytoplasm of osteoblasts is basophilic due to the presence of a large amount of rough endoplasmic reticulum. The nucleus is spherical and large. An active osteoblast is characterized morphologically by a prominent Golgi apparatus that appears histologically as a clear zone adjacent to the nucleus. Active osteoblasts synthesize, and stain positively for, Type-I collagen and alkaline phosphatase.
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Osteoblast (Wright Giemsa stain, 100x)
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Osteoblasts lining bone (bottom) and actively synthesizing osteoid, containing two osteocytes.
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Osteoblasts actively synthesizing osteoid (center).
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Osteoblasts actively synthesizing rudimentary bone tissue (center).
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Osteoblasts lining bone (H&E stain).
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Osteoblasts (pointer) lining bone (H&E stain).
Read more about this topic: Osteoblast
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