Clinical Significance
Mutations in OTX2 can cause eye disorders including anophthalmia and microphthalmia.
It has been shown that if Otx2 is over expressed it can lead to childhood malignant brain tumors called medulloblastomas.
Read more about this topic: Orthodenticle Homeobox 2
Famous quotes containing the word significance:
“Of what significance the light of day, if it is not the reflection of an inward dawn?—to what purpose is the veil of night withdrawn, if the morning reveals nothing to the soul? It is merely garish and glaring.”
—Henry David Thoreau (1817–1862)
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