Orozco is of Spanish/Basque origin, and may refer to :
- Ana María Orozco (b. 1973), a Colombian television actress
- Andrés Orozco (b. 1979), a Colombian football defender
- Antonio Orozco (b. 1972), a Spanish singer-songwriter
- Daniel Orozco, an American writer of fiction
- Edwin Orozco (b. 1982), a Colombian road cyclist
- Esther Orozco (b. 1945), a Mexican biologist and researcher
- Gabriel Orozco (b. 1962), a Mexican postminimalist artist
- Germán Orozco (b. 1976), an Argentine field hockey defender
- John Orozco (b. 1992), an American gymnast
- Jonathan Orozco, a Mexican football player
- José Clemente Orozco (1883-1949), a famous Mexican social realist painter, who specialized in bold murals
- Lisseth Orozco (b. 1986), a Colombian judoka
- Michael Orozco Fiscal (b. 1986), an American soccer player
- Olga Orozco (1920-1999), an Argentine poet
- Pascual Orozco(sometimes spelled Oroszco) (1882–1915), a Mexican revolutionary leader
- Rafael Orozco (rarely, Rafael Orozco Flores) (1946-1996), a Spanish classical pianist
- Rafael Orozco Maestre (1954 - 1992) a Colombian musician and singer, one of the major representatives of the Vallenato music.
- Soledad Orozco de Avila Camacho, first lady of Mexico (1940 – 1946); her husband was Manuel Avila Camacho.
- Verónica Orozco, a Colombian actress and singer, Ana María Orozco sister
- Orozco a music album by León Gieco
- Juan Orozco, Spanish luthier and guitar impresario, famous guitar shop in New York (1970s to 1990s)