Orai1

ORAI1

Identifiers Symbols ORAI1; CRACM1; ORAT1; TMEM142A External IDs OMIM: 610277 MGI: 1925542 HomoloGene: 13117 GeneCards: ORAI1 Gene

Gene Ontology
Molecular function	• protein binding • store-operated calcium channel activity
Cellular component	• integral to plasma membrane • protein complex
Biological process	• store-operated calcium entry • blood coagulation • regulation of calcium ion transport • positive regulation of calcium ion transport
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 84876 109305 Ensembl ENSG00000182500 ENSMUSG00000049686 UniProt Q96D31 Q8BWG9 RefSeq (mRNA) NM_032790 NM_175423 RefSeq (protein) NP_116179 NP_780632 Location (UCSC) Chr 12:
122.06 – 122.08 Mb Chr 5:
123.02 – 123.03 Mb PubMed search

Calcium release-activated calcium channel protein 1 is a calcium selective ion channel that in humans is encoded by the ORAI1 gene. Orai1 channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans The mammalian orai family has two additional homologs, orai2 and orai3. Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form tetramers.