Opie may refer to:
- Surnames
- Alan Opie, (born 1945), baritone singer
- Amelia Opie (1769-1853), English author - wife of John Opie
- Catherine Opie, (born 1961), American artist and photographer
- Eugene Lindsay Opie (1873-1971), American pathologist
- Iona Opie, (born 1923), specialist in children's literature, and the customs of schoolchildren - wife of Peter Opie
- John Opie, (1761-1807), Cornish historical and portrait painter - husband of Amelia Opie
- Julian Opie, British artist, famed for his use of vector-based reproductions
- Lisa Opie, (born 1963), English squash player
- Peter Opie, (1918-1982) English specialist in children's literature, and the customs of schoolchildren - husband of Iona Opie
- First or second given names or nicknames
- James Opie Urmson (1915 – 2000s), British philosopher
- Opie, nickname for film director Ron Howard, after his child star role Opie Taylor on The Andy Griffith Show
- Characters
- Opie Winston, fictional character on Sons of Anarchy
- Opie Taylor, fictional character on The Andy Griffith Show
- Films
- Opie Gets Laid, a romantic comedy film distributed by Vivendi Entertainment
- Other uses
- Opie, California, former town
- Opie Ortiz, artist specializing in tattoos, pop art and murals
- OPIE user interface (Open Palmtop Integrated Environment), a completely open-source-based graphical user interface for PDAs and other devices running Linux
- OPIE Authentication System, a one-time password authentication system for Unix based on S/KEY
- Gregg "Opie" Hughes, one half of Opie and Anthony