Oligonucleotide Synthesis - History

History

The evolution of oligonucleotide synthesis saw four major methods of the formation of internucleosidic linkages and has been reviewed in the literature in great detail.

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    “History is the present. That’s why every generation writes it anew. But what most people think of as history is its end product, myth.”
    —E.L. (Edgar Lawrence)

    “Books of natural history aim commonly to be hasty schedules, or inventories of God’s property, by some clerk. They do not in the least teach the divine view of nature, but the popular view, or rather the popular method of studying nature, and make haste to conduct the persevering pupil only into that dilemma where the professors always dwell.”
    —Henry David Thoreau (1817–1862)

    “Regarding History as the slaughter-bench at which the happiness of peoples, the wisdom of States, and the virtue of individuals have been victimized—the question involuntarily arises—to what principle, to what final aim these enormous sacrifices have been offered.”
    —Georg Wilhelm Friedrich Hegel (1770–1831)