The term ODT can refer to several things, among them:
- ODT The Outdoors Trader A popular free online outdoors classifieds site based in the Southeastern US. Their logo reads simply ODT.
- .ODT, the word processing file format of OpenDocument, an open standard for electronic documents
- Otago Daily Times — New Zealand's oldest daily newspaper
- O.D.T., Or Die Trying, is a video game created by Psygnosis for the PlayStation and PC
- On-line Debugging Tool, a debugger used by certain software from Digital Equipment Corporation
- On Die Termination, a technique to reduce bounce back of electrical signals on high speed electrical connections
- Orally disintegrating tablet, drugs that "melt" on contact with saliva
- Objective Dvorak Technique, a technique used to estimate the strength of a tropical cyclone
- Omnidirectional treadmill, a treadmill which can convey objects in two dimensions
- Omnidirectional transmission, an active sonar transmission mode
- Oracle Developer Tools
- Oven dry tonne, a unit to express the dried weight of an agricultural commodity such as biomass that contained significant water weight when harvested
- Order—disorder transition