Structure of OA1 Protein
Human Oa1 gene product was initially identified as a 60kDa protein formed from a 46-48kDa precursor. The OA1 disease is due to defect in the OA1 receptor. This receptor has been shown to be similar to class C G- protein coupled receptors (GPCR). OA1 receptor has a characteristic GPCR structure-7 transmembrane helices with 3 cytoplasmic loops and 3 extracellular loops and an extracellular N- terminus and cytoplasmic C-terminus. Recently the ligand activating this receptor was found. A recent computational work has provided some insight into the three dimensional structure of this protein and its dynamic interactions with its known ligands.
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