In Adult Stem Cells
Several studies suggest a role for Oct-4 in sustaining self-renewal capacity of adult somatic stem cells (i.e. stem cells from epithelium, bone marrow, liver, etc.). Other scientists have produced evidence to the contrary, and dismiss those studies as artifacts of in vitro culture, or interpreting background noise as signal, and warn about Oct-4 pseudogenes giving false detection of Oct-4 expression. Oct-4 has also been implicated as a marker of cancer stem cells. In in-vitro experiments of murine Embryonic Stem Cells, Oct-4 has often been used as a marker of stemness, as differentiated cells show reduced expression of this marker.
Read more about this topic: Oct-4
Famous quotes containing the words adult, stem and/or cells:
“When children dress like adults they are more likely to behave as adults do, to imitate adult actions. It is hard to walk like an adult male wearing corduroy knickers that make an awful noise. But boys in long pants can walk like men, and little girls in tight jeans can walk like women.”
—David Elkind (20th century)
“The lotus’ stem is as long as the depth of water,
So men’s height is just as great as their inner strength.”
—Tiruvalluvar (c. 5th century A.D.)
“Madness is locked beneath. It goes into tissues, is swallowed by the cells. The cells go mad. Cancer is their flag. Cancer is the growth of madness denied.”
—Norman Mailer (b. 1923)