Ocrl

OCRL

Identifiers Symbols OCRL; INPP5F; LOCR; NPHL2; OCRL-1; OCRL1 External IDs OMIM: 300535 MGI: 109589 HomoloGene: 233 GeneCards: OCRL Gene EC number 3.1.3.36

Gene Ontology
Molecular function	• phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity • protein binding • Rac GTPase activator activity • Rac GTPase binding • inositol phosphate phosphatase activity
Cellular component	• photoreceptor outer segment • nucleus • cytoplasm • early endosome • Golgi stack • Golgi-associated vesicle • trans-Golgi network • cytosol • plasma membrane • coated pit • clathrin-coated vesicle • phagocytic vesicle membrane • early endosome membrane
Biological process	• in utero embryonic development • lipid metabolic process • phospholipid metabolic process • phosphatidylinositol biosynthetic process • small GTPase mediated signal transduction • regulation of Rac GTPase activity • positive regulation of Rac GTPase activity • cilium assembly • inositol phosphate metabolic process • small molecule metabolic process • phosphatidylinositol dephosphorylation • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 4952 320634 Ensembl ENSG00000122126 ENSMUSG00000001173 UniProt Q01968 Q6NVF0 RefSeq (mRNA) NM_000276 NM_177215 RefSeq (protein) NP_000267 NP_796189 Location (UCSC) Chr X:
128.67 – 128.73 Mb Chr X:
47.91 – 47.97 Mb PubMed search

Inositol polyphosphate 5-phosphatase OCRL-1 (INPP5F), also known as Lowe oculocerebrorenal syndrome protein, is an enzyme encoded by the OCRL gene located on the X chromosome in humans.